Intranuclear trafficking of transcription factors: implications for biological control
نویسندگان
چکیده
منابع مشابه
Intranuclear trafficking: organization and assembly of regulatory machinery for combinatorial biological control.
The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatoria...
متن کاملIntranuclear trafficking
Nucleic acids and regulatory proteins involved in gene expression and DNA replication are localized in specialized subnuclear domains that can be visualized by microscopy. However, the rules that govern the compartmentalization of the nucleus into these discrete domains have been elusive. From an historical perspective, the concept of nuclear subdivisions as functional compartments initially fo...
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The family of runt related transcription factors (RUNX/CbfaiAML/PEBP2) are essential for cellular differentiation and fetal development. RUNX factors are distrjbuted throughout the nucleus jn punctate focj that are assocjated with the nuclear matrix/scaffold and generally correspond with sjtes of active transcrjption. Truncations of RUNX proteins that eliminate the C-terminus including a 3l-ami...
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Sp1 and Sp3 are ubiquitously expressed mammalian transcription factors that activate or repress the expression of a variety of genes and are thought to compete for the same DNA binding site. We used indirect immunofluorescence microscopy and image deconvolution to show that Sp1 and Sp3 are organized into distinct nonoverlapping domains in human breast and ovarian cells. Domains of Sp1 and Sp3 i...
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Since both major forms of diabetes involve inadequate function of pancreatic beta cells, intensive research is ongoing to better understand how beta cells perform their complex role of secreting the hormone insulin in response to physiologic needs. Identification and characterization of pancreatic transcription factors has revealed that they play a crucial role not only in maintenance of mature...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2000
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.113.14.2527